简介
杨祚璋，男，外科学博士，第二军医大学临床医学博士后，博士生导师，博士后联系导师，昆明医科大学硕士生导师（外科学及肿瘤学方向）、昆明理工大学医学院硕士生导师（肿瘤基础研究方向），国家百千万人才工程入选者，国家有突出贡献中青年专家，云岭名医，享受云南省政府特殊津贴专家。云南省骨与软组织肿瘤诊治研究中心主任，云南省临床重点专科（骨与软组织肿瘤）主任，云南省骨与软组织肿瘤防治研究省创新团队首席科学家，云南省骨与软组织肿瘤防治科技公共服务平台主任。云南省医学领军人才，云南省高层次人才医学科带头人（肿瘤学），云南省中青年学术与技术带头人，昆明市中青年学术和技术带头人，德国外科学会会员，中国抗癌协会肉瘤专业委员会全国委员及骨转移学组委员，中国医药教育协会骨与软组织肿瘤专委会常委，中国医促会骨肿瘤学组全国委员，国家自然科学基金同行评议专家，云南省抗癌协会肉瘤专业委员会主任委员，云南省医学会肿瘤学青委会副主任委员，云南省医学会手外科分会副主任委员，云南省骨科医师分会脊柱学组副组长，云南省修复重建外科委员会常委，云南省医学会骨科学分会委员，云南省医学会医疗事故技术鉴定专家。曾在美国梅奥诊所（Mayo Clinic）、德国慕尼黑大学附属医院( Klinikum Grosshadern)骨肿瘤科、意大利博洛尼亚Rizzoli医院脊柱肿瘤中心、意大利罗马Gemelli医院骨与软组织肿瘤中心做Clinical Fellow，在希腊、新加坡、泰国等国短期学习。担任多个SCI收录杂志Editor或审稿人，担任多个国内医学杂志编委。主编专著《骨转移癌的诊断与治疗》。主持国家自然科学基金重点项目1项，面上及地区基金4项，中国博士后基金2项、云南省及昆明市重点项目4项。在Mol Cancer（SCI， IF：10.68）、Nature子刊Cell Death Differ（ SCI， IF：8.339）、Theranostics（ SCI， IF：8.85）、Lancet子刊Ebiomedicine（SCI， IF：6.68）、Nature子刊Cell Death Dis（SCI， IF：5.96）、INT J BIOCHEM CELL B（SCI， IF：4.86）、Eur Spine J（SCI， IF：2.473）等国外知名期刊以通讯作者身份发表论文30多篇，主要学术观点多次被包括Nature在内的顶级杂志引用，总被SCI引用800余次，单篇被引频次最高230次。获国家发明专利8项，实用新型专利2项，1项国际专利已获PTC认证。获云南省科技进步特等奖1项（排名第一），一等奖2项（1项排名第一，1项第四），三等奖3项，昆明市科技进步二等奖2项。获国际MASCC2011 Young Investigators award奖(欧洲)。获2015年云南省青年科技奖。现在招收博士后4人（1人为留学生）、博士研究生生2人（1人为留学生）、已培养硕士研究生20余人（1人为留学生）。从事与软组织肿瘤专业工作十余年，擅长四肢、骶骨、骨盆、脊柱肿瘤的外科治疗、恶性骨与软组织肿瘤的化疗，以及骨转移瘤的综合治疗（尤其是微创外科治疗）。一、主持科研项目（部分）1. 非编码RNA通过调控自噬和程序性坏死网络影响云南宣威肺腺癌骨转移的功能和机制研究（No.U1702283），国家自然科学基金联合重点项目,204万，2018.01-2021.122. 氟伐他汀通过ferroptosis与自噬抑制肺腺癌骨转移的作用和机制研究(No.81972764), 国家自然科学基金面上项目,57万，2020.01-2023.123. MicroRNA通过调控自噬影响肺腺癌骨转移的分子机制研究（No. 81372322）, 国家自然科学基金面上项目,73万，2014.01-2017.12(已结题)4. MicroRNA-106a通过P53信号网络调节细胞自噬及肺腺癌骨转移的机制研究(No.81460440), 国家自然科学基金地区基金项目,46万，2015.01-2018.12（已结题））5. 氟伐他汀通P53/AMPK/mTOR通路诱导自噬抑制人肺腺癌细胞骨转移的实验研究（No.81260322），国家自然科学基金地区基金项目,45万，2013.01-2016.12（已结题）二、获奖项目（部分）：1. 杨祚璋（排名第1），肿瘤骨转移机制及诊疗关键技术创新与应用, 获2019年度云南省科技进步特等奖。1.杨祚璋（排名第1），脊柱转移瘤的微创新技术研究及临床应用，获2014年度云南省科技进步一等奖。2. .杨祚璋（排名第4），昆明43医院骨科省创新团队，获2015年度云南省科技进步一等奖。3. 杨祚璋（排名第1），脊柱转移瘤的个体化综合治疗，获2008年度云南省科技进步三等奖。3. 杨祚璋（排名第2），四肢骨巨细胞瘤的生物学行为研究及个体化治疗，获2017年度云南省科技进步三等奖。三、获知识产权情况授权相关发明专利[1] YANG Zuozhang, ZHANG Ya, YANG Yihao, LI Xiaojuan, LI Dongqi, XIA Junfeng, LI Su, ZHANG Zhaoxin, LI Huiling, CHEN Yanjin. miRNA marker for diagnosing Osteosarcoma[P]. 专利号：PCT/CN2016/106567. （已获国际专利PCT认证，授权时间2018年）[2]杨祚璋，谢琳，许达，李东奇，杨义豪，张娅. NPR3基因在制备诊断试剂盒中的用途[P].专利号：ZL 201410321627.7（已授权，授权时间2016年）[3]杨祚璋，张娅，许达，陈彦锦，刘雪峰，许达.一种诊断试剂盒及PPT1基因及其制备中的用途[P].专利号：ZL 201410321626.2（已授权，授权时间2017年）[4]杨祚璋，张曌昕，夏俊峰，李惠玲，张娅，李素.作为骨肉瘤诊治靶标的miRNA[P].专利号：ZL 201610003305.7（已授权，授权时间2018年）[5]杨祚璋，杨义豪，李东奇，张娅.骨肉瘤的miRNA诊断标志物[P]. 专利号：ZL 201610578751.0（已授权，授权时间2019年）[6]杨祚璋，李晓娟，李东奇，陈彦锦，杨义豪. Mir-1292及其靶基因在预防和治疗骨肉瘤转移中的应用[P].专利号：ZL201610003247.8（已授权，授权时间2019年）[7]杨祚璋，谢琳，徐磊，李国奇.一种检测肺癌骨转移试剂盒[P].专利号：ZL 201210347230.6（已授权，授权时间2013年）[8]杨祚璋，谢琳，徐磊，李国奇. 一种肺癌骨转移荧光定量PCR检测试剂盒[P].专利号：ZL 201210347229.3（已授权，授权时间2013年）[9]杨祚璋，谢琳，孙洪瀑，王青. 一种一次性螺旋注射器及其应用[P].专利号：ZL201110081315.X（已授权，授权时间2013年）授权相关实用新型专利[1]杨祚璋，谢琳，孙洪瀑，王青. 一种新型的一次性螺旋注射器[P].专利号：ZL201120092739.1（已授权，授权时间2012年）[2]杨祚璋，袁涛，孙洪瀑，徐磊.一种125I粒子照射细胞实验的装置[P].专利号：ZL 201220441309.0（已授权，授权时间2013年）三、Publications第一作者或通讯作者文章[1]Zhenyi Su, Zuozhang Yang（杨祚璋，通讯作者），Yongqing Xu, Yongbin Chen and Qiang Yu. Apoptosis, autophagy, necroptosis, and cancer metastasis.Mol Cancer,2015,14(1):48 (SCI收录, IF=10.68)[2]Z Su, Z Yang（杨祚璋，通讯作者），Lin Xie, JP DeWitt, Y Chen. Cancer therapy in the necroptosis era. Cell Death Differ, 2016, 23(5):748-756. (Nature 子刊，SCI收录,IF=8.339)[3]Zuozhang Yang（杨祚璋，通讯作者）, Lin Xie, Lei Han, Xin Qu, Yihao Yang, Ya Zhang, Zewei He, Yu Wang, Jing Li. Circular RNAs: Regulators of Cancer-Related Signaling Pathways and Potential Diagnostic Biomarkers for Human Cancers. Theranostics, 2017,7(12):3106-3117. (SCI收录, IF=8.712)[4]Zuozhang Yang（杨祚璋，通讯作者），Zhenyi Su, Judy Park DeWitt, Lin Xie, Yongbin Chen, Xiaojuan Li, Lei Han, Dongqi Li, Junfeng Xia, Ya Zhang, Yihao Yang, Congguo Jin, Jing Zhang, Su Li, Kun Li, Zhiping Zhang, Xin Qu, Zewei He, Yanjin Chen, Yan Shen, Mingyan Ren, Zhongqin Yuan. Fluvastatin Prevents Lung Adenocarcinoma Bone Metastasis by Triggering Autophagy. EbioMedicine, 2017,19:49–59. (lancet子刊，SCI收录，IF=6.68)[5]Zhihong Yao, Lei Han, Yongbin Chen, Fei He, Bin Sun, Santosh kamar, Ya Zhang, Yihao Yan,Cao Wang, Zuozhang Yang（杨祚璋，通讯作者）. Hedgehog signalling in the tumourigenesis and metastasis of osteosarcoma, and its potential value in the clinical therapy of osteosarcoma. Cell Death Dis,2018, 9:701. (SCI收录, IF=5.965)[6]Lin Xie, Zhihong Yao, Ya Zhang, Dongqi Li, Fengdi Hu, Yedan Liao, Ling Zhou, Yonghong Zhou, Zeyong Huang, Zeiwei He, Lei Han, Yihao Yang, Zuozhang Yang（杨祚璋，通讯作者）. Deep RNA sequencing reveals the dynamic regulation of miRNA, lncRNAs and mRNAs in osteosarcoma tumorigenesis and pulmonary metastasis. Cell Death Dis,2018. (SCI收录, IF=5.965)[7]ZhangYa, He Zewei, Duan Yanping, WangCao, Santoshi Kamar, ShiXiaoqian, Yang Jifei, Yang Jingqing , ZhaoNa , Han Lei, Yang Yihao , YangZuozhang（杨祚璋，通讯作者）. Does intensifed chemotherapy increase survival outcomes of osteosarcoma patients? A meta-analysis. Journal of Bone Oncology,2018. (SCI收录, IF=3.5)[8]Lin Xie, Yedan Liao, Lida Shen, Fengdi Hu, Sunlin Yu, Yonghong Zhou, Ya Zhang, Yihao Yang, Dongqi Li, Minyan Ren, Zhongqin Yuan, Zuozhang Yang（杨祚璋，通讯作者）. Identification of the miRNA-mRNA regulatory network of small cell osteosarcoma based on RNA-seq. Oncotarget, 2017, 8(26): 42525-42536. (SCI收录, IF=5.168)[9]Ya Zhang, Zeiwei He, Yi Li, Yihao Yang, Jiandang Shi, Xuefeng Liu, Tao Yuan, Junfeng Xia, Dongqi Li, Jing Zhang, Zuozhang Yang（杨祚璋，通讯作者）. Selection of Surgical Methods in the Treatment of Upper Tibia Osteosarcoma and Prognostic Analysis. Oncol Res Treat, 2017,40:528–532. (SCI收录, IF=1.66)[10]Yichun Yang, Lei Han, Zewei He, Xiaojuan Li, Suping Yang, Jifei Yang, Ya Zhang, Dongqi Li, Yihao Yang,（杨祚璋，通讯作者）. Advances in limb salvage treatment of osteosarcoma. Journal of Bone Oncology, 2018,10:36–40. (SCI收录, IF=1.471)[11]Zhenyi Su, Zuozhang Yang（杨祚璋，通讯作者）, Yongqing Xu, Yongbin Chen, Qiang Yu.MicroRNAs in apoptosis, autophagy and necroptosis.Oncotarget,2015,6(11):8474-90 (SCI收录, IF=6.627)[12]Jing Li, Zuozhang Yang( ), Yi Li, Junfeng Xia, Dongqi Li, Huiling Li, Mingyan Ren, Yedan Liao, Shunling Yu, Yanjin Chen, Yihao Yang and Ya Zhang. Cell apoptosis, autophagy and necroptosis in osteosarcoma treatment.Oncotarget, 2016 Mar 19. (SCI收录, IF=5.168)[13]Zuozhang Yang（杨祚璋，通讯作者）, Xiaojuan Li, Yihao Yang, Wei He, Xin Qu, and Ya Zhang. Long Non-coding RNAs in the progression, metastasis and prognosis of osteosarcoma. CELL DEATH DIS.2016.7.29 (Nature 子刊，SCI收录,IF=5.965)[14]YiHao Yang,Ya Zhang,Xin Qu,Junfeng Xia,Dongqi Li,XiaoJuan Li,Yu Wang,Zewei He,Su Li,Yonghong Zhou and Zuozhang Yang（杨祚璋，通讯作者），Identification of differentially expressed genes in the development of osteosarcoma using RNA-seq.Oncotarget, 2016.(SCI收录，IF=5.008)[15]Dongqi Li, Jinlei Zhang, Yi Li, Junfeng Xia, Yihao Yang, Mingyan Ren, Yedan Liao, Shunling Yu, Xiaojuan Li, Yan Shen, Ya Zhang and Zuozhang Yang（杨祚璋，通讯作者）， Surgery methods and soft tissue extension are the potential risk factors of local recurrence in giant cell tumor of bone. World J Surg Oncol, 2016,14(1):114 (SCI收录,IF=1.408)[16]Yihao Yang, Mingyan Ren, Zhongqin Yuan, Kun Li, Zhiping Zhang, Jing Zhang, Lin Xie and Zuozhang Yang（杨祚璋，通讯作者）， Thoracolumbar paravertebral giant ganglioneuroma and scoliosis: a case report and literature review. World J Surg Oncol, 2016,14(1):65 (SCI收录,IF=1.408)[17]Jing Zhang, Zuozhang Yang, JianDong. P62: An emerging oncotarget for osteolytic metastasis. J Bone Oncol, 2016, 5(1):30-7(SCI收录,IF=3.5)[18]Xiaojuan Li, Ya Zhang, Shanshan Wan, Huiling Li, Dongqi Li, Junfeng Xia, Zhongqin Yuan, Mingyan Ren, Shunling Yu, Su Li, Yihao Yang, Lei Han, Zuozhang Yang（杨祚璋，通讯作者）. A Comparative study between limb-salvage and amputation for treating osteosarcoma. J Bone Oncol, 2016,5(1):15–21(SCI收录,IF=3.5)[19]Jing Zhang, Jian Dong, Zuozhang Yang（杨祚璋，通讯作者），Xiang Ma, Jinlei Zhang Mei Li, Yun Chen, Yingying Ding,Kun Li and Zhiping Zhang.Expression of ezrin, CD44, and VEGF in giant cell tumor of bone and its significance.World J Surg Oncol,2015,13(1):168 (SCI收录,IF=1.408)[20] Lin Xie, Yanjin Chen, Ya Zhang, Zuozhang Yang（杨祚璋，通讯作者），Zhaoxin Zhang, Lida Shen, Zhongqin Yuan and Mingyan Ren.Status and prospects of percutaneous vertebroplasty combined with (125)I seed implantation for the treatment of spinal metastases.World J Surg Oncol,2015,13(1):119(SCI收录,IF=1.96)[21] Hongpu Sun,Zuozhang Yang（杨祚璋，通讯作者），Yongqing Xu,Xuefeng Liu, Ya Zhang,Yanjin Chen, DaXu,Yihao Yang, Dongqi Li &Junfeng Xia. Safety of percutaneous vertebroplasty for the treatment of metastatic spinal tumors in patients with posterior wall defects. Eur Spine J, 2015,24(8): 1768-1777. (SCI收录, IF=2.473)[22]Zuozhang Yang（杨祚璋，通讯作者），Yihao Yang, Ya Zhang, Zhaoxin Zhang, Yanjin Chen, Yan Shen, Lei Han, Da Xu and Hongpu Sun.Minimal access versus open spinal surgery intreating painful spine metastasis: a systematic review. World J Surg Oncol, (2015) 13:68. (SCI收录,IF=1.408)[23] Sanxiong Xu,Zuozhang Yang（杨祚璋，通讯作者），Jinyu Zhang,Yongxin Jiang,Yongbin Chen, Hongjun Li,Xuefeng Liu,Da Xu,Yanjin Chen,Yihao Yang,Ya Zhang,Dongqi Li,and Junfeng Xia.Increased levels of beta-catenin, lef-1, and hpa-1 correlate with poor prognosis for acral melanoma with negative braf and nras mutation in braf exons 11 and 15 and nras exons 1 and 2. DNA Cell Biol,2015,34(1):69-77. (SCI收录,IF=2.574)[24] Zuozhang Yang（杨祚璋，通讯作者），Yongbin Chen, Yu Fu, Yihao Yang, Ya Zhang, Yanjin Chen，Dongqi Li. Meta-analysis of differentially expressed genes in osteosarcoma based on gene expression data. BMC Medical Genetics, 2014, 15:80 (SCI收录，IF=2.450)[25] Piccioli A, Rossi B, Scaramuzzo L, Spinelli MS,Yang Z（杨祚璋，通讯作者），Maccauro G.Pathologic fractures of the Intramedullary nailing for treatment of pathologic femoral fractures due to metastases. Injury. 2013 Sep 19. pii: S0020-1383(13)00434-8. (SCI收录, IF=2.174)[26] Lin Xie, ZuozhangYang（杨祚璋，通讯作者）， Guoqi Li, Leda Shen, Xudong Xiang, Xuefeng Liu,Da Xu. Genome-wide identification of bone metastasis-related microRNAs in lung adenocarcinoma by high-throughput sequencing.Plos One,2013, 8(4):e61212 (SCI收录, IF=4.092)[27] Jing Zhang, Zuozhang Yang（杨祚璋，通讯作者），Lin Xie, Lei Xu , Da Xu, Xuefeng Liu. Statins, autophagy and cancer metastasis. Int J Biochem Cell B,2013,45(3):745-752. (SCI收 录,IF=4.634)[28] Zuozhang Yang （杨祚璋，通讯作者），Jing Tan, Ruilian Zhao, Jiaping Wang, Hongpu Sun, Xiaoxue Wang, Lei Xu, Hua Jiang, Jinlei Zhang. Clinical Investigations on the Spinal Osteoblastic Metastasis Treated by Combination of Percutaneous Vertebroplasty and (125)I Seeds Implantation Versus Radiotherapy. Cancer Biother Radio,2013,28(1):58-64. (SCI收录,IF=1.78)[29]Zuozhang Yang（杨祚璋，通讯作者），Yu Zhang,Da Xu,Giulio Maccauro,Barbara Rossi, Hua Jiang, Jiaping Wang, Hongpu Sun, Lei Xu,YanjinChen and Xuefeng Liu. Percutaneous vertebroplasty combined with interstitial implantation of 125I seeds in banna mini-pigs. World J Surg Oncol, 2013,11:46 (SCI收录, IF=1.408)[30] Zhang J, Yang Z（杨祚璋，通讯作者），Wang J, Wang J, Liu P, Sun H, Li K, Yang Y. Study of treatment using percutaneous acetabuloplasty and interstitial implantation of 125I seeds for patients with metastatic periacetabular tumors. World J Surg Oncol, 2012,10:250. (SCI收录,IF=1.408)[31] Xie L, Shen LD, Qing C, Yang ZZ（杨祚璋，通讯作者），Li K, Li Y, Correlational study of vascular endothelial growth factor expression and microvessel density in primary malignant gastric lymphoma .Medical Oncology,2012,29(3):1711-1715. (SCI收录,IF=2.486)[32] Yang Z（杨祚璋，通讯作者），Tan J, Xu Y, Sun H, Xie L, Zhao R, Wang J, Jiang H.Treatment of MM-associated spinal fracture with percutaneous vertebroplasty (PVP) and chemotherapy. Eur Spine J, 2012,21(5):912-915. (SCI收录, IF=2.473)[33] Zuozhang Yang（杨祚璋，通讯作者），Yongqing Xu, Dakuan Yang, Hongpu Sun, Ruilian Zhao, Jin Zhang,Xiaoxue Wang, Hua Jiang, Lie Xu and Jinlei Zhang. Pathological Impairments Induced by Interstitial Implantation of 125I Seeds in Spinal Canal of Banna Mini-Pigs. World J Surg Oncol,2012, 10:48. (SCI收录,IF=1.408)[34] Zuozhang Yang（杨祚璋，通讯作者），Congguo Jin, Ting Chen, Hongpu Sun, Dakuan Yang, Yunchao Huang, Jin Zhang, Ruilian Zhao, Jinlei Zhang. Changes in cell cycle, apoptosis and necrosis following the establishment of a 125I brachytherapy model in the spinal cord in Banna mini-pigs .Oncology letters, 2012,3(2):315-320 . (SCI收录,IF=1.87)[35] Zuozhang Y（杨祚璋，通讯作者）， Lin X, Hongpu S, Yunnchao H, Xiang M, Tao Y, Jinlei Z, Ruilian Z..Treating a patient with T5-metastatic lung cancer and spinal cord compression by percutaneous vertebroplasty and 125I seed implantation: a case report. Diagn Interv Radiol,2011,17(4):384-387. (SCI收录,IF=1.406)[36] Zuozhang Yang（杨祚璋，通讯作者），Yongqing Xu, Lei Xu,Giulio Maccauro, Barbara Rossi, Yanjin Chen, Hongjun Li, Jing Zhang, Hongpu Sun, Yihao Yang, Da Xu, Xuefeng Liu. Regulation of Autophagy via PERK-eIF2α Effectively Relieve the Radiation Myelitis induced by Iodine-125. Plos One,2013, 8(11):e76819 (SCI收录, IF=4.092)[37] Li R, Liu Y, Wang T, Tang J, Xie L, Yao Z, Li K, Liao Y, Zhou L, Geng Z, Huang Z, Yang Z(杨祚璋，通讯作者), Han L. The characteristics of lung cancer in Xuanwei County: A review of differentially expressed genes and noncoding RNAs on cell proliferation and migration. Biomed Pharmacother. 2019 ,119:109312. (SCI收录,IF=3.74)非第一作者文章[38]Shi Y, Fan S, Wu M, Zuo Z, Li X, Jiang L, Shen Q, Xu P, Zeng L, Zhou Y, Huang Y, Yang Z(杨祚璋), Zhou J, Gao J, Zhou H, Xu S, Ji H, Shi P, Wu DD, Yang C, Chen Y. YTHDF1 links hypoxia adaptation and non-small cell lung cancer progression.. Nat Commun. 2019 ,10(1):4892. doi: 10.1038/s41467-019-12801-6. (SCI收录,IF=11.87)
